Настольный небольшой ЯМР-магнитный наносенсор, технология быстрого обнаружения

Настольный небольшой ЯМР-магнитный наносенсор, технология быстрого обнаружения

With the development of nanotechnology, biofunctionalized superparamagnetic nanoparticles (connected with different biomolecules, such as nucleic acids, small molecules, peptides, антитела) have been widely developed in terms of biological enrichment and identification. The biofunctionalized magnetic beads are enriched on biomacromolecules, causing the change of transverse relaxation time (Т2) in the system. This T2 change can be sensitively detected by low-field nuclear magnetic resonance. Combining the two can construct a new type of biomolecular recognition method with extremely low detection limit, strong specificity and rapidity. В настоящий момент, this technology has been applied to the detection of toxins, viruses, bacteria, heavy metals, and pathogenic bacteria.

Настольный небольшой ЯМР-магнитный наносенсор, технология быстрого обнаружения

The basic principle of the detection mechanism of magnetic nanosensors is based on the ability of selective nanoparticles to switch between dispersed and aggregated states when interacting with the target. Variety. On the basis of T2 (ΔT2) changes, various molecular targets such as nucleic acids (DNA and mRNA), белки, and viruses can be detected.

Benchtop small NMR detection object

1. Viruses
2. Small molecules, peptides
3. Nucleic acids (DNA and mRNA)
4. Bacteria, food-borne pathogens
5. Immunoglobulin
6. Toxins
7. Heavy Metals

Benchtop small NMR instrument parameters:

Probe coil diameter: 15мм

Sample dosage: 0.5-2ml

Advantages of Benchtop small NMR

1. Strong specificity (detection requires specific magnetic beads)
2. Быстрый
3. Accurate
4. Very low detection limit
5. Высокая чувствительность
6. Измерения необученным персоналом
7. Field testable