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A Gadolinium(III) Complex with 8-amidequinoline Based Ligand as Copper(II) Ion Responsive Contrast Agent

 A Gadolinium(III) Complex with 8-amidequinoline Based Ligand as Copper(II) Ion Responsive Contrast Agent


Abstract 

A new Cu2+-responsive MRI contrast agent (Gd-QDOTAMA) with a quinoline-based ligand was synthesized and characterized. Relaxivity studies on Gd-QDOTAMA showed that the relaxivity increased from 4.27 mM-1 s-1 to 7.29 mM-1 s-1 in response to equimolar amounts of copper(II) ion,corresponding to ca. 71% relaxivity enhancement. Distinct changes in relaxivity were undetected upon addition of physiologically relevant alkali metal cations (K+ or Na+), alkaline earth metal cations (Mg2+
or Ca2+), or d-block metal cations (Zn2+, Cu+, Fe2+, Fe3+), indicating a high selectivity for Cu2+ over other biologically relevant metal ions. Moreover, the influence of common biological anions at physiological levels on the Cu2+-responsive contrast agent was also studied. Luminescence studies on the Eu counterpart Eu-QDOTAMA suggest that the enhancement in relaxivity for Gd-QDOTAMA in response to Cu2+ is most likely due to the increased number of inner-sphere water molecules around
Gd3+ upon Cu2+ binding to the 8-amidequinoline moiety. In vitro T1-weighted phantom images of Gd-QDOTAMA confirmed that signal intensity was markedly increased by the addition of equimolar amounts of Cu2+.


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